Thank an ancient squirrel, climate change and French scientists for the new discovery of an ancient virus, Mollivirus sibericum, that sounds like it could launch a creepy movie.
"Actually there's already a science-fiction novel inspired by one of our last (discoveries). Look on Amazon," said Jean-Michel Claverie, a professor of medical genomics and bioinformatics at the University Of Mediterranean School Of Medicine in Marseille, France. "But with the ancient squirrel, I can see where you might think movie."
The
virus has been at rest for 30,000 years about 30 meters deep in the
Siberian permafrost. Astrobiologists using it as kind of stand-in for Mars have taken core samples looking for life. Claverie said he stumbled on research that described reviving a plant
from a seed that had been buried for 30,000 years. What intrigued
Claverie was that the particular core sample came into contact with an
ancient squirrel's nest.
"And what do
all squirrels do all their life? They store seeds for eating," Claverie
said. Wondering what else they might find, he sent the scientists an
email that launched collaboration between Russian and French research
teams and led to several discoveries.
Waking an ancient virus
When
Claverie's team got the sample, they knew they'd have to be careful to
protect animals and humans from whatever was in it; they weren't sure if
they'd wake up Captain America or the Winter Soldier.
"We're not stupid enough to revive a virus that may pose a threat to human health," Claverie said.
So, they went fishing. "We use amoeba as bait to fish out whatever viruses may be in that specific sample," Claverie said.
The amoeba was the type typically found in contact lens infections. The team grew them, then mixed in parts of the permafrost samples in a petri dish. Most of the time, nothing happened.
"But
every once in a while, we see them die and that's when we know somebody
must be killing them," Claverie said. "This way, we know which to
isolate from the others." Scientists say they are safeguarding the virus
sample.
Using this technique has led to several discoveries -- Mollivirus sibericum is the latest of four
giant viruses found so far in this one sample. It's called a "giant"
virus because you can see it under a light microscope, like a bacteria,
and it has a large number of genes.
The
name comes from Molli, a hard-to-translate French word that essentially
means something that is soft or flexible, Claverie said, and Sibericum
for the location where it was found.
"The name is a little mundane compared to the last giant virus we found 'the Pandoraviruses,'" he said. "Mollivirus sibericum, though could be as equally dangerous as what is in Pandora's Box, based on its behavior.
"It
was a very low concentration of these viruses that infected the amoeba.
If you think about it, it's really scary that only a handful of
particles might be sufficient enough to start an epidemic."
Which
is why, in the paper Claverie and his team published in a recent
edition of PNAS, they express concern about other ventures into the
permafrost.
What's hiding in the permafrost?
As climate change
has opened up new maritime routes through the arctic sea ice, Claverie
and his team worry about the increasing number of companies already mining for gold and tungsten along the northern coast of Siberia.
The companies will excavate millions of tons of permafrost that have lain undisturbed for thousands and thousands of years.
If this one core sample yielded at least four giant viruses, there is no telling what frozen surprises could be suddenly exposed in open mining.
"What may be in those layers is very worrying," Claverie said.
But
they may also hold great promise. Secrets there could unlock a new
understanding of metabolic pathways and biochemical processes that could
lead to the creation of new drugs and biotechnology.
Or
that ancient squirrel could lead us to something even bigger, Claverie
wrote: "Part of what we don't know might turn out to contain the
explanation to fundamental questions such as the origin of life on our
planet."
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